The team signed Matt Gay to the practice squad on Wednesday, cutting wide receiver Russell Gage Jr. from the practice squad ...

The San Francisco 49ers won't get star WR Brandon Aiyuk back in time for their Week 12 matchup against the Carolina Panthers.

The San Francisco 49ers are facing a kicker crisis after Eddy Piñeiro sustained a hamstring injury. Coach Kyle Shanahan has ...

USA Today's NFL experts make their picks for a Week 12 showdown between the San Francisco 49ers and Carolina Panthers ...

The 49ers are dropping a running back to bring back No. 3 quarterback Adrian Martinez. San Francisco released practice-squad ...

Signs pointed toward CB Deommodore Lenoir not being able to play for the San Francisco 49ers on Sunday, but their inactives ...

It wouldn't be a normal victory Monday for the San Francisco 49ers without Kyle Shanahan providing discouraging injury news.

The San Francisco 49ers will meet the Arizona Cardinals on Sunday for the second time this year, but they might be without a ...

The Minnesota Vikings could be looking for a quarterback trade with the San Francisco 49ers amid J.J. McCarthy's struggles.

The San Francisco 49ers on Thursday had a true rarity to open the day's practice. ESPN's Nick Wagoner reported every member ...

The Arizona Cardinals and San Francisco 49ers revealed their final inactives report for Week 11 - who's in, who's out?

SANTA CLARA, Calif. (AP) — Brock Purdy returned to the lineup and the San Francisco 49ers scored their most points in nearly ...