Before making any Week 12 NFL picks or NFL score predictions on those games or others, you need to see the NFL against the spread, over/under and money line predictions powered by the self-learning SportsLine AI. New users can target the DraftKings promo code, which offers $200 in bonus bets if your bet wins + 3 months of NBA League Pass:

Our NFL Week 12 early picks against the spread start with Josh Allen and the Bills vs. the Texans on Thursday night.

San Francisco is a good team to use at this point in the season. The 49ers’ future value is moderate when compared to the other big favorites in Week 12. They do have upcoming games at Cleveland and vs. Tennessee, but finish the year against Indianapolis, Chicago, and Seattle – all vying for playoff spots.

DFS millionaire Mike McClure shares his top daily fantasy football picks and lineup advice for Texans vs. Bills on 'Thursday Night Football'

While Los Angeles Rams quarterback Matthew Stafford (+150) and New England Patriots quarterback Drake Maye (+185) remain at the top, the rest of the MVP race saw plenty of shake-ups.

The Texans have a chance to continue their hot streak and gain ground in the playoff hunt. A victory would give them the edge over the Jacksonville Jaguars entering next week and