UC San Diego structures show E. coli RNA polymerase reads four synthetic DNA letters the same way it reads the natural four.

Viral replication relies fundamentally on specialised DNA polymerases that orchestrate genome synthesis, fidelity control and interaction with viral and host factors. These enzymes exhibit remarkable ...

DNA polymerases orchestrate the faithful replication and repair of genomes through a coordinated sequence of substrate binding, chemical catalysis and product release. Central to this process are ...

An essential cellular enzyme successfully transcribed synthetic DNA letters, bringing expanded genetic codes closer to biological use.

Loop-mediated isothermal amplification (LAMP), a DNA amplification technique valued for its speed, specificity, sensitivity, and simplicity, is increasingly employed in disease diagnostics and ...

Scientists have shown that biology can read an eight-letter DNA alphabet, opening new possibilities for synthetic life and ...

Promega Corporation has launched Paradyme™ 27GY STR System, the first commercially available short tandem repeat (STR) analysis kit to include the company’s Reduced-Stutter Polymerase (RSP). This ...

Researchers at the University of Bristol have caught DNA-copying enzymes generating long stretches of genetic code without any template to guide them, a behavior the team calls “doodling.” Published ...

A research group led by the University of Osaka has discovered that the DNA repair enzyme Polβ plays a crucial role in protecting the developing brain from harmful mutations. The study found that a ...

Promega files patent for first-of-its-kind enzyme that minimizes stutter artifacts in STR analysis Reduced stutter polymerase enhances accuracy, efficiency and reliability of DNA profiling in forensic ...

Biology lectures teach students that when a cell’s replication machinery comes together, DNA polymerase takes off down the double-helix like a car on a highway ...

A soybean enzyme better known for its role in plant hormone chemistry has been unmasked as an unexpected accomplice of a ...