A drug used to help the heart pump blood and lower blood pressure may reduce the risk of deteriorating heart function in infants and children soon after heart surgery, according to a study published ...

Background: Neonates are at particular risk of suffering surgery-related LCOS, characterized by impaired myocardial contractility and the peripheral effects of ischemia/reperfusion on endothelium.

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Endothelin-1 (ET-1) is a 21-amino acid polypeptide produced primarily by vascular endothelial cells. First discovered in 1988 as a potent vasoconstrictor, it has subsequently been appreciated to ...