Nature

Cleavage of BCR–ABL transcripts at the T315I point mutation by DNAzyme promotes apoptotic cell death in imatinib-resistant BCR–ABL leukemic cells

In this study, we designed DNAzymes that specifically target and cleave the junction sequence and/or the site of point mutation conferring T315I drug resistance in BCR–ABL mRNA. The designed DNAzymes ...
Nature

Regulation of the c-Abl and Bcr–Abl tyrosine kinases

Abl is a non-receptor tyrosine kinase that contains a Src-homology-3 (SH3)- and a Src-homology-2 (SH2)-domain. Abl participates in many signalling pathways in the cytoplasm and the nucleus. The ...