Because NF1 is an unpredictable disorder, it varies widely in severity – even among two people in the same family. Some people with NF1 may be completely unaware that they are affected, experiencing ...

It can spawn tumors throughout the nervous system and bone deformities that riddle the whole body with pain. One of the most common rare diseases in the world, the genetic condition neurofibromatosis ...

Malignant peripheral nerve sheath tumors (MPNSTs) are aggressive sarcomas that arise from benign plexiform neurofibroma (PN) and borderline atypical neurofibroma (AN) in the setting of ...

In mapping out future directions for NF1 research, the CABIN task force aims to bring about a “cycle of discovery, preclinical evaluation, and clinical translation.” Neurofibromatosis type 1 (NF1) is ...

Panelists discuss how neurofibromatosis type 1 (NF1) is typically diagnosed in early childhood using National Institutes of Health (NIH) clinical criteria, with genetic testing supporting unclear ...

NF-1 is a genetic condition that causes brown skin patches, similar to birthmarks, and tumours 1. While the tumours are often benign, they can become cancerous over time and may cause a range of ...

In previous blogs, I’ve discussed to the fact that NF is a highly variable condition that can manifest differently among affected individuals. For example, two people within the same family can have ...

Share on Facebook. Opens in a new tab or window Share on Bluesky. Opens in a new tab or window Share on X. Opens in a new tab or window Share on LinkedIn. Opens in a new tab or window A decade of ...

Neurofibromatosis type 1 (NF1) is a genetic condition that causes tumors to grow along nerves in the skin, brain, and other parts of the body. These tumors are usually noncancerous (benign), but they ...

The US Food and Drug Administration has approved mirdametinib for the treatment of neurofibromatosis type 1 (NF1) in adults and children. The drug, developed by SpringWorks Therapeutics, is the first ...