Some forms of synaptic plasticity involve changes in the probability of presynaptic synaptic vesicle release, but the mechanisms remain poorly understood. In this study, Midorikawa and Sakaba suggest ...

Hailed as one of the most important medical advances, the discovery of general anesthetics—compounds that induce unconsciousness, prevent control of movement and block pain—helped transform dangerous ...

The paper S.S.H. Wang et al., “Fusion competent synaptic vesicles persist upon active zone disruption and loss of vesicle docking,” Neuron, 91:777-91, 2016. Hair trigger Neurons send each other ...

Interactions of two voltage-gated calcium channels and a pump enable separate control of exocytosis and endocytosis at chemical synapses. Chemical synapses transmit information within the nervous ...

Vesicle recycling in the presynaptic terminal at one end of a neuron, showing the role of dynamin during the last step of endocytosis (membrane retrieval), where the protein cuts off the vesicle from ...

Neurons are connected to each other through synapses, sites where signals are transmitted in the form of chemical messengers. Reinhard Jahn, Director at the Max Planck Institute for Biophysical ...