I am writing to express my displeasure regarding the letter to the editor by Julian Tyson (C&EN, March 14/21, 2022, page 5) about “metal-free” reactions (Feb. 14, 2022, page 20). Specifically, my ...

Mechanochemical synthesis harnesses mechanical energy to drive chemical transformations under solvent‐minimised or solvent-free conditions. This approach, frequently executed by ball milling or liquid ...

With artificial intelligence, scientists can design increasingly complex small molecule structures. Automation is critical for transforming these compounds from designs on a screen into actual ...

Synthesis of organic compounds and polymers is at the core of many manufacturing industries. The new “electrifying synthesis” methods that can combine conventional synthetic chemistry with ...

Highly reactive organometallic reagents, like organolithiums (molecules with a carbon–lithium bond) are essential reagents in organic synthesis because of their applications from polymer synthesis to ...

This module explores the synthesis of amines with a focus on the reductive amination reaction. Numerous examples from the discovery and commercial manufacturing of pharmaceuticals are included. After ...

Electrochemical reactions for synthesis of organic compounds would find wider applications if they were independent of power supply. Now, researchers have exploited the flow of electrolytes in an ...