While biomarkers have transformed Alzheimer’s research, much work remains to be done to develop these important tools for other neurodegenerative diseases, not to mention for the concurrent ...
Different genetic mutations can converge on the same downstream pathology. The C9ORF72 repeat expansion and progranulin haploinsufficiency both trigger the RNA-binding protein TDP-43 to abandon the ...
A team of researchers has developed a laboratory model that recapitulates the pathological aggregation of TAR DNA-binding protein 43 (TDP-43), a hallmark of amyotrophic lateral sclerosis (ALS) and ...
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