A massive genomics effort has identified thousands of single nucleotide non-coding variants, which alter gene activity, that link to disease and health.

The non-coding genome, once dismissed as "junk DNA", is now recognized as a fundamental regulator of gene expression and a key player in understanding complex diseases. Following the landmark ...

Scientists have identified how specific genetic changes function in cells to influence disease risk and other human health ...

Image Caption: Technologies evolved related to the Human Genome Project. Genes & Diseases publishes rigorously peer-reviewed and high quality original articles and authoritative reviews that focus on ...

Human DNA constantly refolds in 3D space, and these looping dynamics regulate gene expression and cell identity.

For decades, biologists have known that the instructions for life are written in DNA, yet the vast majority of those letters seemed to sit in the dark, doing little that was obvious. Now a new ...

An illustration of multicolored tangle of threads within a small black sphere. A 3D illustration shows DNA packaged into the nucleus, scientists with the 4D Nucleome project are now building accurate ...

All living organisms face the problem of parasites — entities that thrive on others, often at the hosts’ expense. As a result, life is characterized by the presence of defence systems that keep such ...

How much of our genome really matters? Some argue that because most of our DNA is active, it must be doing something important. Others say even random DNA would be highly active. This has now been put ...