Gut

Global epidemiology of disorders of gut–brain interaction: new insights with Rome V

Following publication of the Rome V diagnostic criteria for disorders of gut–brain interaction (DGBI) earlier this year,1 the ...
Gut

A durably colonising engineered native symbiont enables sustained intestinal delivery for metabolic dysfunction and colitis

Background Engineered bacterial therapeutics represent a promising strategy for sustained intestinal delivery of therapeutic ...
Gut

Coordinated cellular programmes distinguish responses to neoadjuvant PD-L1 blockade and potentiate combinatorial immunotherapy in ESCC

Background Programmed death ligand 1 (PD-L1) blockade offers new therapeutic options for oesophageal squamous cell carcinoma ...
Gut

Divergent microbial preludes to necrotising enterocolitis defined by gut phages and bacterial resistomes

Background Translating microbiome correlations into robust predictive features for complex gut disorders remains elusive, ...
gut.bmj

Functional bowel disorders and functional abdominal pain

The Rome diagnostic criteria for the functional bowel disorders and functional abdominal pain are used widely in research and practice. A committee consensus approach, including criticism from ...
gut.bmj

International expert panel review for the use of resmetirom and semaglutide in the management of MASH-related fibrosis: clinical practice update

The recent conditional US Food and Drug Administration (FDA) approval of two therapies, resmetirom (Rezdiffra) and semaglutide (Wegovy), marks the first time clinicians have pharmacological therapy ...
gut.bmj

Microbiota and diabetes: an evolving relationship

Correspondence to Professor Herbert Tilg, Department of Internal Medicine I, Gastroenterology, Endocrinology & Metabolism, Medical University Innsbruck, Innsbruck 6020, Austria; ...
gut.bmj

YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition

Correspondence to Shumei Song, Departmental of GI Medical Oncology, U.T.MD. Anderson Cancer Center, Houston, TX 77030, USA; ssong{at}mdanderson.org; Jaffer A Ajani ...
gut.bmj

New frontier in albumin replacement therapy

Albumin is a multifunctional protein with pleiotropic activity that is produced almost exclusively in the liver. From many studies in several patient groups, it has become clear that in patients with ...
gut.bmj

FODMAPs alter symptoms and the metabolome of patients with IBS: a randomised controlled trial

Objective To gain mechanistic insights, we compared effects of low fermentable oligosaccharides, disaccharides and monosaccharides and polyols (FODMAP) and high FODMAP diets on symptoms, the ...
gut.bmj

Incidence and prevalence of ulcerative colitis in Punjab, North India

1 Department of Medicine, Dayanand Medical College and Hospital, Punjab, India 2 Department of Pathology, Dayanand Medical College and Hospital, Punjab, India 3 Department of Community Medicine, ...
gut.bmj

Treatment of non-constipated irritable bowel syndrome with the histamine 1 receptor antagonist ebastine: a randomised, double-blind, placebo-controlled trial

Correspondence to Professor Guy Boeckxstaens, Department of Chronic Diseases, Metabolism, and Ageing, KU Leuven, Leuven, Belgium; guy.boeckxstaens{at}kuleuven.be Objective We evaluated the histamine 1 ...