RMD Open

Early SLE may follow a fast comorbidity/multimorbidity trajectory associated with flare burden and glucocorticoid exposure

Background Patients with systemic lupus erythematosus (SLE) carry a substantial comorbidity load associated with worse prognosis, yet most evidence pertains to long-standing disease. How comorbidities ...
RMD Open

Risk of cognitive disorders in patients with primary Sjögren’s disease: data from Korean Health Insurance Service

Objective To investigate the risk of incident cognitive disorders in patients with primary Sjögren’s disease (pSjD) using nationwide Korean National Health Insurance Service data.Methods This ...
RMD Open

Distinct molecular signature in relapsed patients with ANCA-associated vasculitis

Objectives The pathogenesis of relapses in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) remains ill defined. We aimed to identify whether there are any ...
rmdopen.bmj

Factors associated with the effectiveness and safety of Janus kinase inhibitors in rheumatoid arthritis: an 8-year observational study from the JAGUAR Registry

Objectives To identify factors associated with the effectiveness and safety of Janus kinase (JAK) inhibitors in patients with rheumatoid arthritis (RA), as reflected by treatment retention. Methods ...
rmdopen.bmj

Pollutants: a candidate as a new risk factor for osteoarthritis—results from a systematic literature review

Background Considering non-classical environmental risk factors for osteoarthritis (OA), a systematic literature review (SLR) was performed to summarise existing knowledge on associations between OA ...
rmdopen.bmj

Physical activity in patients with rheumatoid arthritis - an agile lifelong behaviour: a qualitative meta-synthesis

Background Physical activity (PA) in rheumatoid arthritis (RA) is considered a cornerstone in the treatment. To highlight aspects involved in supporting a positive PA behaviour, it is important to ...
rmdopen.bmj

Infliximab biosimilar-to-biosimilar switching in patients with inflammatory rheumatic disease: clinical outcomes in real-world patients from the DANBIO registry

Objective Successful uptake of biosimilars in rheumatology is limited by lack of real-world evidence regarding effectiveness of biosimilar-to-biosimilar switching. We investigated infliximab ...
rmdopen.bmj

Comparative analysis of instruments measuring peripheral arthritis activity in Spondyloarthritis: a measurement properties study in 13 RCTs

Objectives Using randomised controlled trial (RCT) data, this study evaluated the measurement properties of selected instruments to assess peripheral arthritis in axial and peripheral ...
rmdopen.bmj

Incidence, baseline-associated factors and burden of difficult-to-manage axial spondyloarthritis: a 10-year analysis of the DESIR cohort

Objective To determine the cumulative incidence of difficult-to-manage axial spondyloarthritis (D2M-axSpA) and treatment-refractory axSpA (TR-axSpA) in a recent-onset axSpA inception cohort, identify ...
rmdopen.bmj

Predicting disease flares in axial spondyloarthritis using different machine learning models in the METEOR-SpA registry

Objectives To develop and externally validate machine learning models for predicting disease flares in axial spondyloarthritis (axSpA) using real-world registry data. Methods Patients with axSpA ...
rmdopen.bmj

Assessment and personalised advice for fatigue in systemic lupus erythematosus using an innovative digital tool: the Lupus Expert system for the Assessment of Fatigue (LEAF) study

Background Fatigue is reported as the most prevalent symptom by patients with systemic lupus erythematosus (SLE). Fatigue management is complex due to its multifactorial nature. The aim of the study ...