The gut microbiota have a known role in modulating gut immune homeostasis. Largely, through the development and function of host immune cells, including T helper cells expressing interleukin-17A. It ...

A long-standing mystery in bile acid biology has been solved. Bile acids are often introduced as digestion helpers, but they are also powerful chemical messengers that help coordinate metabolism ...

Examining gut health from a different angle, Flinders University’s Associate Professor Robyn Meech is looking at what can trigger colon cancer – and she believes bile acids may provide a significant ...

Immunotherapy is a modern approach to cancer treatment that uses a patient's own immune system to help fight tumors. It has made an incredible impact on treating cancers in many different organ ...

Bile acids are essential to digestion, by acting like a kind of detergent that breaks up fat molecules. Fat doesn't dissolve in water, but our digestive system is full of water, so the fat we consume ...

Researchers at EPFL have made a surprising discovery about how bile acids act as signaling molecules to boost intestinal regeneration. The discovery sheds light on the role of bile acids as ...

Using cryo-EM structure determination, molecular dynamics simulations, and electrophysiological analyses, researchers from the Shanghai Institute of Materia Medica of the Chinese Academy of Sciences ...

As the owner of a human body, you're carrying trillions of microbes with you everywhere you go. These microscopic organisms aren't just hitching a ride; many of them perform essential chemical ...

Habegger is a professor in the UAB Department of Medicine Division of Endocrinology, Diabetes and Metabolism and also a scientist in the UAB Nutrition Obesity Research Center who studies how glucagon ...

(A) The classic bile acid synthesis pathway: cholesterol 7α-hydroxylase (CYP7A1) converts cholesterol to 7α-hydroxycholesterol (7α-HOC). The sterol 12α-hydroxylase (CYP8B1) converts the intermediate ...