Real Madrid beat Atletico Madrid in a Champions League penalty shootout — again — to keep its title defense alive Wednesday and advance to the quarterfinals.

Another consequential week of UEFA Champions League action will wrap up Wednesday as the round of 16 comes to a close and four more teams will book a spot in the quarterfinals. Arsenal look to follow Bayern Munich's Tuesday example and convert a major first-leg advantage into advancement into the last eight,

With the second leg of the UEFA Champions league against Atletico Madrid around the corner, Real Madrid have the risk of losing two star players for Wednesday game.

Villareal takes on Real Madrid at the Estadio de la Cerámica on Saturday, March 15. Kickoff is set for 6:30 p.m. CET local time, making it a 1:30 p.m. ET and 10:30 a.m. PT start in the US, a 5:30 p.m. GMT start in the UK and a 4:30 a.m. AEDT kickoff in Australia on Sunday.

After beating rivals Atletico Madrid on penalties in the second leg of the Champions League Round of 16, Real Madrid will visit Villarreal on Saturday for another key La Liga clash before the international break.

Real Madrid were taken to the brink by bitter rivals Atletico in the Champions League. Now their attention returns to a three-pronged title race in LaLiga.