The Major Histocompatibility Complex is a genetic region characterized by a high density of genes, many of them involved in the immune response. Of considerable importance are the HLA class I and ...

Class I major histocompatibility complex (MHC-I) proteins play an essential role in the immune system of all jawed vertebrates. The MHC-I displays peptide fragments of proteins from within the cell on ...

Sex differences in parasite load and immune responses are found across a wide range of animals, with females generally having lower parasite loads and stronger immune responses than males. Intrigued ...

Understanding drivers of genetic diversity at the major histocompatibility complex (MHC) is vitally important for predicting how vertebrate immune defence might respond to future selection pressures ...

T cells are a critical part of the adaptive immune system that respond to pathogens, tumors, or play a key role in autoimmune diseases. A T cell recognizes potential targets through its T cell ...

Major Histocompatibility Complex (MHC) molecules display antigens to T cells, immune cells that constantly check for infected or damaged cells. If T cells spot MHC molecules with foreign antigens or ...

Scientists have uncovered a surprising new way the immune system fights cancer, overturning a core belief that has guided immunology for decades. The research found that when cancer cells shut down a ...

Many modern cancer treatments, including immunotherapy, depend on activating killer T cells to recognise and destroy tumours.

Major histocompatibility complex (MHC) is a collection of genes involved in immunological recognition of self. It is necessary for cell self-recognition and the prevention of the immune system ...