The nucleus inside a cell is an important organelle involved in almost all biological phenomena, such as DNA replication and transcription.

How chromatin responds to transcription-blocking DNA lesions is unclear. This study reveals that RNA polymerase II (RNAPII) ...

Maeshima and colleagues have revealed that the local chromatin motion remains steady throughout interphase, although genome DNA is doubled by DNA replication and the nucleus grows.

DNA often experiences torsional stress inside living cells, whether through the packing of chromosomes in the nucleus or the ...

Within the nucleus of every cell are long strings of DNA, the code that holds all the information needed to make and control every cell within a living organism. DNA, which stands for ...

CGGBP1 binds to short CGG repeats in gene promoters, recruiting RNA:DNA helicases like DDX41 to ensure proper transcription ...

These nucleosome dynamics facilitate chromatin accessibility to large proteins (purple), which in turn help regulate key genomic processes such as DNA replication and transcription.

Unexpected slowdowns or spikes in this signal were often interpreted as knots in DNA. But now, a new study published Aug. 12 ...

DNA repair enzymes, such as the ligase shown here that joins broken DNA strands, scan replicating DNA in the nucleus. Particularly difficult cases are now known to be transported to the inner edge ...