This image shows a metastatic melanoma tumor in a lung. Blood vessels at the tumor site (yellow) express a protein called P-selectin. Blood vessels not expressing P-selectin are green. Nanoparticles ...

Selectins are required for the trafficking of innate immune system cells, T lymphocytes and platelets. The absence of selectins or their ligands has severe health consequences, with recurrent ...

Circulating neutrophils must avoid premature activation to prevent tissue injury. The leukocyte adhesion receptor L-selectin forms bonds with P-selectin glycoprotein ligand-1 (PSGL-1) on other ...

Dynamics of growth of transplantable sarcoma 45 (S45) in injection of autologous and allogenic serum. Dynamics of IGF-I, IGF-II and TGF-β1 in lung and liver in the early stages of metastasis in ...

The up-regulation of P-selectin in endothelial cells and platelets contributes to the cell–cell interactions that are involved in the pathogenesis of vaso-occlusion and sickle cell–related pain crises ...

When cancer metastasizes, cells break off from the primary tumor, travel through the lymphatic or circulatory system, and then invade other tissue. Now researchers have found a protein that allows ...

An open-label expanded-access study to evaluate the safety, tolerability, and pharmacokinetics of trifluridine/tipiracil in patients with advanced solid tumors and hepatic impairment. This is an ASCO ...

A Princeton-led team of researchers has discovered a factor that promotes the spread of cancers to bone, opening the way toward treatments that could mitigate cancer’s ability to colonize bone. The ...