Evaluation of: He LZ, Crocker A, Lee J et al. Antigenic targeting of the human mannose receptor induces tumor immunity. J. Immunol. 178(10), 6259 - 6267 (2007). Induction of adaptive immune ...

Evan Y. Yu, MD, discusses how individualized first-line systemic therapy selection for metastatic hormone-sensitive prostate cancer (mHSPC) involves considering factors such as disease burden, patient ...

Researchers at the NYU Pain Research Center have found a new receptor for nerve growth factor that plays an important role in pain signaling, even though it does not signal on its own, according ...

Cell signaling is crucial for cells to communicate and function correctly. Disruptions in these pathways, caused by genetic mutations or environmental factors, can lead to uncontrolled cell growth ...

Amidst the wide variety of glycan modifications that are carried out in the Golgi apparatus, the addition of mannose 6-phosphate (M6P) to the N-linked glycans of lysosome-resident hydrolase enzymes ...

TGF-β Pathway: TGF-β is a cytokine that plays a critical role in regulating cellular processes such as proliferation, differentiation, and apoptosis. In the liver, TGF-β signaling is involved ...

Key components of the TGF-β1 pathway, including TGFBR1, TGFBR2, Smad2, Smad3, and Smad4 (Figure 6; Figure S1D), suggest the presence of a canonical TGF-β1 signaling pathway in this early vertebrate.

Background: Numerous treatments with different mechanisms of action are approved for metastatic castration-resistant prostate cancer (mCRPC), but real-world studies increasingly indicate that androgen ...

News Release 28-Jun-2022 No more binge eating: Signal pathway in the brain that controls food intake discovered Peer-Reviewed Publication University of Cologne ...

Androgen receptor (AR) signaling affects response to BRAF/MEK inhibitor therapy in both males and females with melanoma, researchers have shown. The findings provide a new target to combat ...

More information: Hemn Mohammadpour et al, β2-adrenergic receptor signaling regulates metabolic pathways critical to myeloid-derived suppressor cell function within the TME, Cell Reports (2021).