MIT Neuroscientists Discover a Tiny Brain Receptor That Could Transform Fragile X Treatment
MIT neuroscientists have made a breakthrough in treating fragile X syndrome by leveraging a novel neurotransmitter signaling ...
Science Daily1d
Study suggests new molecular strategy for treating fragile X syndrome
A new study shows that enhancing activity of a specific component of 'NMDA' receptors normalizes protein synthesis, neural activity and seizure susceptibility in the hippocampus of fragile X lab mice.
Medscape22d
Human Mannose Receptor (CD206) in Immune Response: Novel Insights into Vaccination Strategies Using a Humanized Mouse Model
2007 Future Drugs Ltd. Cite this: Human Mannose Receptor (CD206 ... can access both MHC class II and cross-presentation pathways in vivo and thus involve both humoral and cellular arms of immune ...
C&EN1mon
Comment on “Self-Illuminating Nanoagonist Simultaneously Induces Dual Cell Death Pathways via Death Receptor Clustering for Cancer Therapy”
Université de Bourgogne, U1231 INSERM, CTM, Equipe DesCarTes, UFR Sciences de Santé, 7 Bd Jeanne d’Arc, 21078 Dijon Cedex, France ...
eLife3y
S-acylation by ZDHHC20 targets ORAI1 channels to lipid rafts for efficient Ca
The results show a novel role for Orai1 acylation in promoting signaling and early activation events upon interaction of T cells with antigen-presenting cells.
Frontiers4y
The Complement C3a and C3a Receptor Pathway in Kidney Diseases
The pathogenesis of some kidney diseases is closely associated with complement activation, where the C3a/C3a receptor (C3aR ... In the lectin pathway, mannose-binding lectin (MBL) binds to the ...
Frontiers5y
CLEC2 and CLEC5A: Pathogenic Host Factors in Acute Viral Infections
It has been shown that activated MyD88 triggers two signaling pathways: (1) the TRAF3-TBK1-IKKε-IRF3 ... are captured by the high affinity receptors DC-SIGN and mannose receptor (MR). The formation of ...
eLife6y
Screening for insulin-independent pathways that modulate glucose homeostasis identifies androgen receptor antagonists
The screen identified three promising candidate drugs, including a molecule that interferes with a receptor for a signal known as androgen. These findings will help researchers investigate new ways to ...
Nature23y
Toll-like Receptors as Sensors of Pathogens
On the basis of their genetic similarity to the Toll signaling pathway in Drosophila ... on the surface of the macrophage. Macrophage mannose receptor and macrophage scavenger receptor are ...