RMD Open

Risk of cognitive disorders in patients with primary Sjögren’s disease: data from Korean Health Insurance Service

Objective To investigate the risk of incident cognitive disorders in patients with primary Sjögren’s disease (pSjD) using nationwide Korean National Health Insurance Service data.Methods This ...
RMD Open

Early SLE may follow a fast comorbidity/multimorbidity trajectory associated with flare burden and glucocorticoid exposure

Background Patients with systemic lupus erythematosus (SLE) carry a substantial comorbidity load associated with worse prognosis, yet most evidence pertains to long-standing disease. How comorbidities ...
RMD Open

Distinct molecular signature in relapsed patients with ANCA-associated vasculitis

Objectives The pathogenesis of relapses in patients with microscopic polyangiitis (MPA) and granulomatosis with polyangiitis (GPA) remains ill defined. We aimed to identify whether there are any ...
rmdopen.bmj

Blinatumomab as the first-line induction for ANCA-associated rapidly progressive glomerulonephritis

Blinatumomab, a CD19×CD3 bispecific T-cell engager approved for B-cell acute lymphoblastic leukaemia,8 induces rapid and profound B-cell depletion and has shown immunomodulatory effects in selected ...
rmdopen.bmj

Evaluating a guideline-aligned prednisone threshold within the Lupus Low Disease Activity State (LLDAS): associations with damage accrual

Objective To examine whether a modified Lupus Low Disease Activity State with a prednisone-equivalent threshold ≤5 mg/day (LLDAS-5) is more strongly associated with lower damage accrual than ...
rmdopen.bmj

Incidence, baseline-associated factors and burden of difficult-to-manage axial spondyloarthritis: a 10-year analysis of the DESIR cohort

Objective To determine the cumulative incidence of difficult-to-manage axial spondyloarthritis (D2M-axSpA) and treatment-refractory axSpA (TR-axSpA) in a recent-onset axSpA inception cohort, identify ...