Gut

Expert consensus on clinical trials for use of systemic therapy in patients with hepatocellular carcinoma undergoing surgical and locoregional therapies

Background Advances in systemic therapy for advanced hepatocellular carcinoma (HCC) have fuelled a growing interest in ...
Gut

Metastatic pancreatic cancer: from human disease to preclinical modelling

Metastatic pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest solid cancers, portending poor patient outcomes ...
Gut

A durably colonising engineered native symbiont enables sustained intestinal delivery for metabolic dysfunction and colitis

Background Engineered bacterial therapeutics represent a promising strategy for sustained intestinal delivery of therapeutic ...
Gut

Coordinated cellular programmes distinguish responses to neoadjuvant PD-L1 blockade and potentiate combinatorial immunotherapy in ESCC

Background Programmed death ligand 1 (PD-L1) blockade offers new therapeutic options for oesophageal squamous cell carcinoma ...
gut.bmj

Impact of non-enteric-coated pancreatic enzyme replacement therapy (NEPERT) on pain in patients with chronic pancreatitis: a double-blind, parallel-group, placebo-controlled ...

Background Pain in chronic pancreatitis (CP) is multifactorial. Efficacy of pancreatic enzyme replacement therapy (PERT) for pain remains uncertain. Objective To assess the effect of ...
gut.bmj

Monogenic diseases associated with intestinal inflammation: implications for the understanding of inflammatory bowel disease

Inflammatory bowel disease (IBD), encompassing Crohn's disease and ulcerative colitis, has multifactorial aetiology with complex interactions between genetic and environmental factors. Over 150 ...
gut.bmj

Alzheimer’s disease-related presenilins are key to intestinal epithelial cell function and gut immune homoeostasis

Objective Mutations in presenilin genes are the major cause of Alzheimer’s disease. However, little is known about their expression and function in the gut. In this study, we identify the presenilins ...
gut.bmj

Psychogenic vomiting: the relation between patterns of vomiting and psychiatric diagnoses.

Department of Psychosomatic Medicine, Kyushu University, Fukuoka, Japan. Fifty nine patients admitted with a diagnosis of psychogenic vomiting were classified into five patterns of vomiting: ...
gut.bmj

Functional bowel disorders and functional abdominal pain

The Rome diagnostic criteria for the functional bowel disorders and functional abdominal pain are used widely in research and practice. A committee consensus approach, including criticism from ...
gut.bmj

Clinical and endoscopic predictors of cytological dysplasia or cancer in a prospective multicentre study of large sessile serrated adenomas/polyps

2 Westmead Clinical School, University of Sydney, Sydney, New South Wales, Australia 10 University of Sydney NHMRC Clinical Trials Centre, Sydney, New South Wales, Australia 11 Institute of Clinical ...
gut.bmj

CTCF-rs705704-SUOX axis is important for the association between hypothyroidism and metabolic dysfunction-associated steatotic liver disease

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be ...
gut.bmj

Hepatocyte nuclear factor 4α attenuates hepatic fibrosis in rats

1 Department of Gastroenterology, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China 2 International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary ...