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Zero goats. A Cologuard® test is intended to screen adults 45 and older at average risk for colorectal cancer. Do not use i f you have had adenomas, have inflammatory bowel disease and certain hereditary syndromes, or a personal or family history of colorectal cancer. A Cologuard test is not a replacement for colonoscopy in high risk patients. Cologuard test performance in adults ages 45-49 is estimated based on a large clinical study of patients 50 and older. False positives and false negatives