Among patients with moderate-to-severe asthma who were receiving a range of inhaled glucocorticoid maintenance therapies, the risk of severe asthma exacerbation was significantly lower with as-needed use of a fixed-dose combination of 180 μg of albuterol and 160 μg of budesonide than with albuterol alone. Learn more about the results of the MANDALA trial, published in NEJM: https://nej.md/3Me7344 Then listen to the latest episode of Beyond Journal Club, a podcast by Core IM in collaboration with
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Albuterol is commonly used as rescue therapy in asthma, but this strategy does not address airway inflammation. The addition of the glucocorticoid budesonide to bronchodilator therapy with albuterol might improve outcomes. https://nej.md/3lKFqnC | The New England Journal of Medicine
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